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Using emergent self-organizing maps to identify marine group II archaea genomic fragments from uncharacterized microbial metagenomic sequences
(Massachusetts Institute of Technology, 2010)
The validity and usefulness of clustering marine group II tetranucleotide signatures using emergent self-organizing maps was investigated. Fosmids from the HF200 library were chosen for sequencing based on end-sequence ...
Modulation of the response to cisplatin by nitric oxide and reactive oxygen species in melanoma cells
(Massachusetts Institute of Technology, 2013)
Malignant melanoma causes the highest mortality rate in skin cancers. Although cisplatin has proved efficacious in the treatment of various solid tumors, melanoma seems particularly resistant to this chemotherapeutic drug. ...
Transcriptional divergence and conservation of human and mouse erythropoiesis
(Massachusetts Institute of Technology, 2014)
Mouse models have been used extensively for decades and have been instrumental in improving our understanding of mammalian erythropoiesis. Nonetheless, there are several examples of variation between human and mouse ...
A computational framework for predicting CHO cell culture performance in bioreactors
(Massachusetts Institute of Technology, 2019)
Breaking the trade-off between speed and productivity is a key milestone across industries. In particular, in the biopharmaceutical industry this trade-off is exacerbated by a highly regulated environment, which hinders ...
Environmental remediation and biofuel production through nanoparticle stimulation of yeast
(Massachusetts Institute of Technology, 2019)
Artificially photosynthetic systems aim to store solar energy and chemically reduce carbon dioxide. These systems have been developed in order to use light to drive processes for carbon fixation into biomass and/or liquid ...
A rapid, flexible and scalable DNA assembly platform for genome engineering and regulated gene expression applications in Plasmodium falciparum
(Massachusetts Institute of Technology, 2015)
Plasmodium falciparum is the deadliest malaria parasite. There is no approved vaccine to prevent this disease, and resistance to available antimalarial drugs is becoming widespread. Identification of parasite genes essential ...
Mitigating the effects of ribosome limitations on synthetic circuits via high-gain sRNA-mediated negative feedback
(Massachusetts Institute of Technology, 2015)
Resource limitations in bacterial cells can present significant hurdles that preclude correct synthetic circuit behavior. In a simple circuit with one constitutively expressed protein and one protein whose expression is ...
Computational modeling and simulation for projectile impact and indentation of biological tissues and polymers
(Massachusetts Institute of Technology, 2017)
Understanding the elastic and viscoelastic responses of biological soft tissues and engineered polymer simulants is of great interest to predicting and preventing penetrative injuries. Detailed understanding of the mechanical ...
A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage
(Massachusetts Institute of Technology, 2011)
Objectives: 1) To perform a quantitative comparison of proteins released to media on combination with cytokine (IL-1[beta[ or TNF-[alpha]) and Injury as compared to either treatment alone, and to thus identify proteins ...
Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
(Massachusetts Institute of Technology, 2012)
Tissue engineering can be applied to develop therapeutic techniques for osteoarthritis, a degenerative disease caused by the progressive deterioration of cartilage in joints. An inherent goal in developing cartilage-replacement ...