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Economic potential for clinically significant in vitro diagnostics
(Massachusetts Institute of Technology, 2009)
In recent years, significant advances have been made in the realm of in vitro diagnostics with the development of novel tests which are able to meaningfully impact the course of a patients' disease management. This ...
Predicting prescription patterns
(Massachusetts Institute of Technology, 2008)
Electronic prescription software is replacing traditional handwritten medication orders. This development however doesn't come without a cost and speed has been one of the most complained about issues. It is important to ...
Trends in U.S. regulatory approvals of the biopharmaceutical therapeutic entities
(Massachusetts Institute of Technology, 2005)
Pharmaceutical productivity, as measured by annual output of new molecular entities and new therapeutic biologics, has fallen significantly since reaching a peak in 1996. According to Food and Drug Administration (FDA) ...
Context identification in electronic medical records
(Massachusetts Institute of Technology, 2004)
In order to automate data extraction from electronic medical documents, it is important to identify the correct context of the extracted information. Context in medical documents is provided by the layout of documents, ...
Health information on the Internet : strategies for assessing consumer needs and improving consumer information retrieval
(Massachusetts Institute of Technology, 2004)
Patients and their family members are increasingly turning to the Internet for health information. However, the search strategies consumers are using to obtain information are often unsuccessful. Since some patients are ...
Mergers and acquisitions in the medical device industry
(Massachusetts Institute of Technology, 2007)
Mergers and acquisitions in the Medical Device Industry are the primary mode of exit for early stage companies. The focus of this thesis is to examine factors which influence the value of these M&A transactions from the ...
A novel polymeric microelectrode array for highly parallel, long-term neuronal culture and stimulation
(Massachusetts Institute of Technology, 2008)
Cell-based high-throughput screening is emerging as a disruptive technology in drug discovery; however, massively parallel electrical assaying of neurons and cardiomyocites has until now been prohibitively expensive. To ...
Proteomics for cancer biomarker discovery
(Massachusetts Institute of Technology, 2007)
Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, ...
Probabilistic modeling of the drug development domain: A Bayesian domain-knowledge application for pharmacovigilance
(Massachusetts Institute of Technology, 2003)
A recent analysis by the Tufts Center for the Study of Drug Development estimates that the cost of developing a single new chemical entity (NCE) into a successful therapeutic agent is $802 million. This figure is largely ...
Concept-value pair extraction from semi-structured clinical reports : a case study using echocardiogram reports
(Massachusetts Institute of Technology, 2004)
The task of gathering detailed patient information from narrative clinical text presents a significant barrier to clinical research. A prototype information extraction system was developed to extract pre-specified findings ...