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Orphan drugs : future viability of current forecasting models, in light of impending changes to influential market factors
(Massachusetts Institute of Technology, 2011)
Interviews were conducted to establish a baseline for how orphan drug forecasting is currently undertaken by financial market and industry analysts with the intention of understanding the variables typically accounted for ...
End of life resuscitation patterns : a socio-demographic study of intensive care unit patients by Sharon L. Lojun.
(Massachusetts Institute of Technology, 2010)
This study investigates the effect of age, gender, medical condition, and daily free text input on classification accuracy for resuscitation code status. Data was extracted from the MIMICII database. Natural language ...
Biomedical data retrieval utilizing textual data in a gene expression database by Richard Lu, MD.
(Massachusetts Institute of Technology, 2010)
Background: The commoditization of high-throughput gene expression sequencing and microarrays has led to a proliferation in both the amount of genomic and clinical data that is available. Descriptive textual information ...
Assessing the impact of tumor evolution on oncology drug development and commercialization
(Massachusetts Institute of Technology, 2011)
This thesis investigates the commercial viability of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs ...
Optimizing a protein-RNA aptamer gene regulatory system using an engineered peptide library
(Massachusetts Institute of Technology, 2011)
For this project, N-terminal and C-terminal peptide library fusions were designed,bconstructed, and screened in order to improve the repression achievable with a novel gene regulatory system. This system, based on the ...
Finding utility for genetic diagnostics in the developing world
(Massachusetts Institute of Technology, 2010)
Genetic testing companies have come under fire lately for an array of reasons. Many direct-to-consumer outfits are being challenged by the federal regulatory authorities, by the physicians' community and by the public ...
Best antibiotics for buccal delivery
(Massachusetts Institute of Technology, 2011)
The purpose of the research was to identify the clinical and commercial benefits of switching from intravenous (IV) to buccal delivery of antibiotics. then, the research continued to select 3-5 antibiotics that best met ...
Mapping healthcare information technology
(Massachusetts Institute of Technology, 2010)
In this thesis I have developed a map of Healthcare Information Technology applications used in the United States for care delivery, healthcare enterprise management, clinical support, research and patient engagement. No ...
Using EMR transactional data for personalize clinical decision support
(Massachusetts Institute of Technology, 2010)
Collective intelligence techniques have been used to predict stock prices, customer purchasing habits, movies and books preferences for years, yet they remain unused in the medical profession. With the increasing adoption ...
The effects of licensing and equity financing cycles on pharmaceutical development
(Massachusetts Institute of Technology, 2011)
The purpose of this paper is to examine the interactions between licensing status, equity issuance cycles, and drug development success at the small pharmaceutical companies that originate these development projects. ...