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Evaluation of postponement in the Drug Product supply chain
(Massachusetts Institute of Technology, 2015)
This thesis evaluates the use of postponement in the Drug Product (DP) supply chain at Amgen, which is characterized by highly variable production lead times. The motivation for the use of postponement in the DP supply ...
Diagnosing intensive care units and hyperplane cutting for design of optimal production systems
(Massachusetts Institute of Technology, 2015)
This thesis provides a new framework for understanding how conditions, people, and environments of the Intensive Care Unit (ICU) effect the likelihood the preventable harm will happen to a patient in the ICU. Two years of ...
Risk mitigation of pipeline assets through improved corrosion modeling
(Massachusetts Institute of Technology, 2015)
Infrastructure has to weather the elements and still function. Gas transmission and distribution piping at a utility are no exception. Atmospheric corrosion deteriorates the integrity of the natural gas system, and utilities ...
Methods for predicting inventory levels in a segmented retail supply chain
(Massachusetts Institute of Technology, 2015)
Inventory is the largest asset on Nike's balance sheet-$3.9 Billion on May 3 1 st, 2014-and a key indicator of supply chain health. With new markets, products, and channels being added to Nike's sales portfolio each year, ...
Analysis and productivity improvement of an automated material handling system through simulation
(Massachusetts Institute of Technology, 2015)
As Amazon.com has grown, the company has invested in warehouse systems similar to those traditionally found in manufacturing. These systems are a complex and interconnected set of manned work processing stations linked ...
Applying constraint-based theory to a complex aerospace manufacturing process
(Massachusetts Institute of Technology, 2015)
A new airplane model is quickly ramping up in production rates, and in order to achieve the organizational targets and commitments, Flow Days, Unit Hours and Cycle Times must be reduced throughout the entire supply chain. ...
Investigation of integrally-heated tooling and thermal modeling methodologies for the rapid cure of aerospace composites
(Massachusetts Institute of Technology, 2015)
Carbon Fiber Reinforced Polymer (CFRP) composite manufacturing requires the CFRP part on the associated tool to be heated, cured, and cooled via a prescribed thermal profile. Current methods use large fixed structures such ...
Process and system variation impacts on 777 wings manufacturing
(Massachusetts Institute of Technology, 2015)
The Boeing 777 has seen an increased the rate of production from one plane every 7 days to one plane every 2.5 days. Wing production has relied on a sizeable work force and the use of overtime to meet this demand. The ...
Analysis and implementation of laboratory automation system
(Massachusetts Institute of Technology, 2015)
Quest Diagnostics is a large company that analyzes millions of medical specimens every day using a variety of analytical equipment. It is implementing a fully automated line in a major laboratory. The automation line is ...
Application of flexible labor and standard work in fulfillment center produce operations
(Massachusetts Institute of Technology, 2015)
This thesis demonstrates the applicability of flexible labor and standard work in increasing labor productivity and improving quality in fulfillment center produce operations. Three hypotheses were tested: (1) labor ...