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Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease
(Massachusetts Institute of Technology, 2007)
Vaso-occlusive crises cause most of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however ...
Genomics research and cultivating serendipity in pharmaceutical drug discovery : assessing the competitiveness of R&D productivity between the West and Asia
(Massachusetts Institute of Technology, 2007)
It has been widely reported that pharmaceutical drug discovery innovation began its major decline somewhere in the last decade of the 20th century. After reaching a historical high of 53 new molecular entities (NMEs) in ...
Green fluorescent protein as a mechanical sensor
(Massachusetts Institute of Technology, 2007)
Inquiry into intracellular and cytoskeletal mechanics requires an intracellular mechanical sensor to verify models of sub-cellular structure dynamics. To this end, the green fluorescent protein (GFP) is considered as a ...
Assessing the economic case for stratified medicine
(Massachusetts Institute of Technology, 2007)
The goal of this study is to explore the economic conditions that favor the joint development of therapeutics and companion diagnostics. I hypothesize that predictive biomarkers can generate economic value in drug development ...
Septic shock : providing early warnings through multivariate logistic regression models
(Massachusetts Institute of Technology, 2007)
(cont.) The EWS models were then tested in a forward, casual manner on a random cohort of 500 ICU patients to mimic the patients' stay in the unit. The model with the highest performance achieved a sensitivity of 0.85 and ...
Investment performance of life-science venture capital investment funds, persistence, and subsector analysis
(Massachusetts Institute of Technology, 2007)
Venture capital investment performance data and performance attribution are not typically published. Venture investors articulate (and sell to LPs) conflicting strategies; the popular business literature and culture is ...
Factors influencing the time for FDA review of medical devices
(Massachusetts Institute of Technology, 2007)
Companies must receive marketing authorization by the Food and Drug Administration (FDA) before they can begin commercial distribution of a new type of medical device in the United States. The premarket approval application ...
Value creation through modernizing Chinese medicine
(Massachusetts Institute of Technology, 2007)
My first hypothesis in this thesis is that there is significant value vested in traditional Chinese medicine that can be captured by converting them into ethical drugs through scientific analysis, screening and validation. ...
Enhancing productivity through effective collaborations : the barriers and enablers of collaboration within geographic bioclusters
(Massachusetts Institute of Technology, 2007)
Increasing competition and specialization of firms in the life sciences industry has led to recognition of the need for collaboration. Bioclusters, the co-location of life sciences entities in a specific geographic area, ...
What future physicians want : a comparative analysis of the perception of medical students and pharmaceutical industry executives regarding the future of pharmaceutical sales
(Massachusetts Institute of Technology, 2007)
The leading publicly traded pharmaceutical companies ("Big Pharma) in the US are facing a commercial crisis - their sales structure collectively consisting of more than 100,000 pharmaceutical sales representatives, originally ...