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Computation and predictive modeling to increase efficiency and performance in cell line and bioprocess development
(Massachusetts Institute of Technology, 2020)
A critical early step in the development of a new biopharmaceutical is the selection of the master cell bank. Per FDA requirements, the same master cell bank must be used for all toxicity and clinical trials, as well as ...
Objective assessment of manufacturing technology investments
(Massachusetts Institute of Technology, 2012)
Amgen is a biotechnology company with manufacturing plants throughout the world. New manufacturing technologies are constantly being developed and implemented in order to address cost, quality, regulation, and competitive ...
Implementation Roadmap and Real Options Analysis for Biopharmaceutical Technology Introduction
(Massachusetts Institute of Technology, 2021-06)
Biologics manufacturing is complex involving several unit operations for drug production. As the industry moves forward, new technologies are introduced to decrease cycle time, reduce costs, and improve quality for these ...
The DNA of a high-performing manufacturing organization : improving operations capability through performance measurement
(Massachusetts Institute of Technology, 2006)
The Broad Institute of MIT, Harvard, and the Whitehead Institute, contains the world's highest-throughput genome sequencing center, which contributed approximately one third of the sequence for the Human Genome Project ...
A framework for analyzing biopharmaceutical product introduction in an emerging market
(Massachusetts Institute of Technology, 2006)
Biopharmaceutical companies are under constant pressure to deliver double-digit growth. In traditional markets such as the U.S., Japan, and the European Union growth is stagnant, and profit margins are falling due to ...
Batch sizing strategy & production load leveling in a multi-step chemical manufacturing process
(Massachusetts Institute of Technology, 2005)
In the last couple of years Eastman Kodak Company went through major changes in its strategic direction. The same disruptive technologies that they helped develop for digital imaging have shaped a new industry, and the ...
Application of process analysis and optimization tools in hit-to-lead and lead optimization phases of drug discovery at EPP, NIBR
(Massachusetts Institute of Technology, 2010)
Given that research is based on innovation, it has been believed that its activities can only be optimized with equipment upgrade, increment in personnel scientific knowledge, development of new analytical software and/or ...
Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
(Massachusetts Institute of Technology, 2013)
This thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a ...
Analyzing and improving throughput of Automated Storage and Retrieval Systems in personal computer manufacturing
(Massachusetts Institute of Technology, 2005)
The content of this thesis draws heavily on work completed during a 6.5 month MIT Leaders for Manufacturing (LFM) internship at Dell Corporation's personal computer manufacturing facility in Lebanon, Tennessee (EG1) from ...
Bioreactor Fill Process Control Using Inline Concentration Measurement
(Massachusetts Institute of Technology, 2014)
Some biopharmaceutical companies have responded to evolution of the competitive landscape by placing additional emphasis on reducing their costs of manufacturing as a means of maintaining competitiveness. The prototypical ...