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Phonological working memory and finiteness marking in typical development
(Massachusetts Institute of Technology, 2015)
The goal of this work was to characterize the maturational trajectory of two core developmental language functions: phonological working memory (PWM) as indexed on nonword repetition (NWR) tasks, and finiteness-related ...
Synthesis of composite hydrogels incorporating D,L-cyclic peptide nanotubes as a platform for materials engineering
(Massachusetts Institute of Technology, 2012)
Composite hydrogels find increasing use as biomaterials because the addition of a filler often improves on the material properties of the original matrix, or provides new optical, magnetic, conductive or bioactive ...
Pricing and reimbursement challenges for fixed dose combination cardiovascular drugs and intravenous oncologies
(Massachusetts Institute of Technology, 2012)
Over the past ten years there has been increasing public concern regarding the rising costs of pharmaceuticals. Drug expenditure is the fastest growing sector of healthcare costs in the United States. The structure of the ...
Assessment of the appropriateness and market opportunity of a point-of-care diagnostic solution for hepatitis C in the United States
(Massachusetts Institute of Technology, 2012)
Hepatitis C (HCV) is the most common bloodborne infection in the United States. Although the incidence of HCV is declining, the burden of the disease is rising, driven by the increasing rates of end-stage liver disease and ...
Human strategies for manipulation of physical objects with complex dynamics
(Massachusetts Institute of Technology, 2020)
Humans are adept at manipulating objects to perform a task, including objects with their own complex dynamics, such as a sloshing cup of coffee or cracking a whip. Humans regularly outperform machines at such physical ...
The Disque Platform for the investigation of islet differentiation to study, treat, and cure Type 1 Diabetes
(Massachusetts Institute of Technology, 2017)
There is a critical health care need to generate large numbers of beta cells for transplantation. In Type 1 Diabetes (T1D), insulin-producing beta cells in the islets of Langerhans within the pancreas, which support glucose ...
A contrast agent for MRI of calcifications in breast cancer
(Massachusetts Institute of Technology, 2013)
Clinical x-ray mammography cannot delineate between hydroxyapatite and calcium oxalate, the respective forms of calcification in malignant and benign breast tumors. The water-poor nature of solid calcifications makes them ...
Can the phased array stimulation strategy be implemented using the advanced bionics cochlear implant?
(Massachusetts Institute of Technology, 2016)
Cochlear implants are devices that aim to restore a measure of hearing to the deaf by converting acoustic signals to electric stimuli delivered to electrodes implanted in the inner ear. Theoretically, the phased array ...
Opportunities and challenges in oncology targeted drug development : an assessment of the use of prevalence and companion diagnostic performance thresholds to guide clinical trial strategies
(Massachusetts Institute of Technology, 2012)
Targeted, especially stratified or biomarker-guided, therapies offer significant advantages over traditional oncology therapies in certain settings. Selecting patients most likely to respond to a drug increases the therapeutic ...
Disease marketing and patient coping : a research study
(Massachusetts Institute of Technology, 2012)
BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...