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Now showing items 1-10 of 12
Opportunities and challenges in oncology targeted drug development : an assessment of the use of prevalence and companion diagnostic performance thresholds to guide clinical trial strategies
(Massachusetts Institute of Technology, 2012)
Targeted, especially stratified or biomarker-guided, therapies offer significant advantages over traditional oncology therapies in certain settings. Selecting patients most likely to respond to a drug increases the therapeutic ...
Understanding the drivers of value creation for biopharmaceuticals around the time of drug launch
(Massachusetts Institute of Technology, 2012)
The purpose of this research is to investigate potential strategic variables that executives at small to mid-sized biopharmaceutical companies should consider during the period of a drug launch. Bringing a product to market ...
The contribution of disease focused nonprofits to biomedical research and development
(Massachusetts Institute of Technology, 2013)
Patient-centered, disease-focused nonprofits are playing an increasingly prominent role in accelerating the development of new diagnostics, drugs, and therapies. They are engaging in a variety of complex venture philanthropic ...
Disease marketing and patient coping : a research study
(Massachusetts Institute of Technology, 2012)
BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...
Human strategies for manipulation of physical objects with complex dynamics
(Massachusetts Institute of Technology, 2020)
Humans are adept at manipulating objects to perform a task, including objects with their own complex dynamics, such as a sloshing cup of coffee or cracking a whip. Humans regularly outperform machines at such physical ...
Economic potential of a point-of-care CD4+ T cell count diagnostic in Mexico : a case study for low-end disruption diagnostics in middle of the pyramid Latin America
(Massachusetts Institute of Technology, 2012)
Disruptive models of innovation are starting to appear in healthcare. In the US, for instance, retail medicine clinics are changing the way in which patients satisfy their basic medical needs. In Mexico, similar retail ...
Market incentives for pandemic influenza vaccines
(Massachusetts Institute of Technology, 2012)
It has been estimated that 100 million plus individuals could perish if a virulent influenza pandemic were to occur. In wake of the 2009-10 H1N1 pandemic and in an era of economic austerity, however, industry lacks clear ...
Retrieval mechanisms in sentence comprehension
(Massachusetts Institute of Technology, 2014)
This work investigates the nature of the memory mechanisms utilized in language comprehension. Through the use of the Speed Accuracy Tradeoff (SAT) paradigm (Wickelgren, 1977), healthy young adults were studied for the use ...
Can the phased array stimulation strategy be implemented using the advanced bionics cochlear implant?
(Massachusetts Institute of Technology, 2016)
Cochlear implants are devices that aim to restore a measure of hearing to the deaf by converting acoustic signals to electric stimuli delivered to electrodes implanted in the inner ear. Theoretically, the phased array ...
Assessment of the appropriateness and market opportunity of a point-of-care diagnostic solution for hepatitis C in the United States
(Massachusetts Institute of Technology, 2012)
Hepatitis C (HCV) is the most common bloodborne infection in the United States. Although the incidence of HCV is declining, the burden of the disease is rising, driven by the increasing rates of end-stage liver disease and ...