In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration

Author(s)
Sangaré, Lamba Omar; Ólafsson, Einar B.; Wang, Yifan; Yang, Ninghan; Julien, Lindsay; ... Show more
Thumbnail
DownloadAccepted version (2.188Mb)
Publisher with Creative Commons License
Terms of use
Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/
Metadata
Show full item record
Abstract
© 2019 Elsevier Inc. Sangaré et al. use a CRISPR screen to determine the in vivo fitness of Toxoplasma genes. They identify a secreted protein, TgWIP, which determines dendritic cell motility and transmigration in the infected host. In mice, TgWIP determines T. gondii dissemination from the site of infection to distant organs.
Date issued
2019-10
URI
https://hdl.handle.net/1721.1/132590.2
Department
Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Journal
Cell Host & Microbe
Publisher
Elsevier BV
ISSN
1931-3128
Collections

Version History

VersionItemDateSummary
21721.1/132590.2*2022-05-16T19:45:28ZPublication information verified/added.
11721.1/1325902021-09-20T18:23:13Z

*Selected version