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Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

dc.contributor.authorShemesh, Or A.
dc.contributor.authorLinghu, Changyang
dc.contributor.authorPiatkevich, Kiryl D.
dc.contributor.authorGoodwin, Daniel
dc.contributor.authorCeliker, Orhan Tunc
dc.contributor.authorGritton, Howard J.
dc.contributor.authorRomano, Michael F.
dc.contributor.authorGao, Ruixuan
dc.contributor.authorYu, Chih-Chieh (Jay)
dc.contributor.authorTseng, Hua-An
dc.contributor.authorBensussen, Seth
dc.contributor.authorNarayan, Sujatha
dc.contributor.authorYang, Chao-Tsung
dc.contributor.authorFreifeld, Limor
dc.contributor.authorSiciliano, Cody A.
dc.contributor.authorGupta, Ishan
dc.contributor.authorWang, Joyce
dc.contributor.authorPak, Nikita
dc.contributor.authorYoon, Young-Gyu
dc.contributor.authorUllmann, Jeremy F.P.
dc.contributor.authorGuner-Ataman, Burcu
dc.contributor.authorNoamany, Habiba
dc.contributor.authorSheinkopf, Zoe R.
dc.contributor.authorPark, Won Min
dc.contributor.authorAsano, Shoh
dc.contributor.authorKeating, Amy E.
dc.contributor.authorTrimmer, James S.
dc.contributor.authorReimer, Jacob
dc.contributor.authorTolias, Andreas S.
dc.contributor.authorBear, Mark F.
dc.contributor.authorTye, Kay M.
dc.contributor.authorHan, Xue
dc.contributor.authorAhrens, Misha B.
dc.contributor.authorBoyden, Edward S.
dc.date.accessioned2022-06-13T15:11:13Z
dc.date.available2021-10-27T19:51:46Z
dc.date.available2022-06-13T15:11:13Z
dc.date.issued2020-08
dc.date.submitted2019-05
dc.identifier.issn0896-6273
dc.identifier.urihttps://hdl.handle.net/1721.1/133248.2
dc.description.abstract© 2020 Elsevier Inc. One-photon fluorescent imaging of calcium signals can capture the activity of hundreds of neurons across large fields of view but suffers from crosstalk from neuropil. Shemesh et al. engineer cell-body-targeted variants of fluorescent calcium indicators and show in mice and zebrafish that artifactual spikes and correlations are greatly reduced.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuron.2020.05.029en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titlePrecision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicatoren_US
dc.typeArticleen_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratory
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineering
dc.contributor.departmentMassachusetts Institute of Technology. Center for Neurobiological Engineering
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.contributor.departmentMcGovern Institute for Brain Research at MIT
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
dc.contributor.departmentPicower Institute for Learning and Memory
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineering
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biology
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MIT
dc.relation.journalNeuronen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2021-08-13T13:56:09Z
dspace.orderedauthorsShemesh, OA; Linghu, C; Piatkevich, KD; Goodwin, D; Celiker, OT; Gritton, HJ; Romano, MF; Gao, R; Yu, C-CJ; Tseng, H-A; Bensussen, S; Narayan, S; Yang, C-T; Freifeld, L; Siciliano, CA; Gupta, I; Wang, J; Pak, N; Yoon, Y-G; Ullmann, JFP; Guner-Ataman, B; Noamany, H; Sheinkopf, ZR; Park, WM; Asano, S; Keating, AE; Trimmer, JS; Reimer, J; Tolias, AS; Bear, MF; Tye, KM; Han, X; Ahrens, MB; Boyden, ESen_US
dspace.date.submission2021-08-13T13:56:10Z
mit.journal.volume107en_US
mit.journal.issue3en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work Neededen_US


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