Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

Author(s)
Sivanand, Sharanya; Vander Heiden, Matthew G
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Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/
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Abstract
© 2020 Elsevier Inc. Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.
Date issued
2020-02
URI
https://hdl.handle.net/1721.1/133548.2
Department
Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Journal
Cancer Cell
Publisher
Elsevier BV
ISSN
1878-3686
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21721.1/133548.2*2022-02-07T14:01:02ZPublication information verified/added.
11721.1/1335482021-10-27T19:53:29Z

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