Poly(ethylene glycol) with Observable Shedding

Author(s)
Gao, Weiwei; Langer, Robert S; Farokhzad, Omid C
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Abstract
A FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off nanoparticles (NPs; see picture). When the NPs were targeted on cancer cell lines, the reducing endosomal environment caused the cleavage of the disulfide bond and the shedding of the PEG layer. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Date issued
2010
URI
https://hdl.handle.net/1721.1/134534.2
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
Angewandte Chemie - International Edition
Publisher
Wiley
Citation
Gao, W. W., R. Langer, and O. C. Farokhzad. "Poly(Ethylene Glycol) with Observable Shedding." Angewandte Chemie-International Edition 49 37 (2010): 6567-71.
Version: Author's final manuscript
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21721.1/134534.2*2022-01-10T21:18:19ZVerified or entered authority metadata.
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