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dc.contributor.authorBajo, Victoria M
dc.contributor.authorNodal, Fernando R
dc.contributor.authorKorn, Clio
dc.contributor.authorConstantinescu, Alexandra O
dc.contributor.authorMann, Edward O
dc.contributor.authorBoyden, Edward S
dc.contributor.authorKing, Andrew J
dc.date.accessioned2021-10-27T20:09:10Z
dc.date.available2021-10-27T20:09:10Z
dc.date.issued2019
dc.identifier.urihttps://hdl.handle.net/1721.1/134788
dc.description.abstractThe brain has a remarkable capacity to adapt to changes in sensory inputs and to learn from experience. However, the neural circuits responsible for this flexible processing remain poorly understood. Using optogenetic silencing of ArchT-expressing neurons in adult ferrets, we show that within-trial activity in primary auditory cortex (A1) is required for training-dependent recovery in sound-localization accuracy following monaural deprivation. Because localization accuracy under normal-hearing conditions was unaffected, this highlights a specific role for cortical activity in learning. A1-dependent plasticity appears to leave a memory trace that can be retrieved, facilitating adaptation during a second period of monaural deprivation. However, in ferrets in which learning was initially disrupted by perturbing A1 activity, subsequent optogenetic suppression during training no longer affected localization accuracy when one ear was occluded. After the initial learning phase, the reweighting of spatial cues that primarily underpins this plasticity may therefore occur in A1 target neurons.
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.isversionof10.1038/s41467-019-10770-4
dc.rightsCreative Commons Attribution 4.0 International license
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceNature
dc.titleSilencing cortical activity during sound-localization training impairs auditory perceptual learning
dc.typeArticle
dc.relation.journalNature Communications
dc.eprint.versionFinal published version
dc.type.urihttp://purl.org/eprint/type/JournalArticle
eprint.statushttp://purl.org/eprint/status/PeerReviewed
dc.date.updated2019-07-19T16:28:44Z
dspace.orderedauthorsBajo, VM; Nodal, FR; Korn, C; Constantinescu, AO; Mann, EO; Boyden, ES; King, AJ
dspace.date.submission2019-07-19T16:28:46Z
mit.journal.volume10
mit.journal.issue1
mit.metadata.statusAuthority Work and Publication Information Needed


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