A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density
Author(s)
Sinnott-Armstrong, Nasa; Sousa, Isabel S.; Laber, Samantha; Rendina-Ruedy, Elizabeth; Nitter Dankel, Simon E.; Ferreira, Teresa; Mellgren, Gunnar; Karasik, David; Rivas, Manuel; Pritchard, Jonathan; Guntur, Anyonya R.; Cox, Roger D.; Lindgren, Cecilia M.; Hauner, Hans; Sallari, Richard; Rosen, Clifford J.; Hsu, Yi-Hsiang; Lander, Eric S.; Kiel, Douglas P.; Claussnitzer, Melina; ... Show more Show less
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Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.
Date issued
2021-03Department
Massachusetts Institute of Technology. Department of BiologyJournal
Cell Metabolism
Publisher
Elsevier BV
ISSN
1550-4131