| dc.contributor.author | Sinnott-Armstrong, Nasa | |
| dc.contributor.author | Sousa, Isabel S. | |
| dc.contributor.author | Laber, Samantha | |
| dc.contributor.author | Rendina-Ruedy, Elizabeth | |
| dc.contributor.author | Nitter Dankel, Simon E. | |
| dc.contributor.author | Ferreira, Teresa | |
| dc.contributor.author | Mellgren, Gunnar | |
| dc.contributor.author | Karasik, David | |
| dc.contributor.author | Rivas, Manuel | |
| dc.contributor.author | Pritchard, Jonathan | |
| dc.contributor.author | Guntur, Anyonya R. | |
| dc.contributor.author | Cox, Roger D. | |
| dc.contributor.author | Lindgren, Cecilia M. | |
| dc.contributor.author | Hauner, Hans | |
| dc.contributor.author | Sallari, Richard | |
| dc.contributor.author | Rosen, Clifford J. | |
| dc.contributor.author | Hsu, Yi-Hsiang | |
| dc.contributor.author | Lander, Eric S. | |
| dc.contributor.author | Kiel, Douglas P. | |
| dc.contributor.author | Claussnitzer, Melina | |
| dc.date.accessioned | 2022-04-04T19:54:55Z | |
| dc.date.available | 2021-10-27T20:22:44Z | |
| dc.date.available | 2022-04-04T19:54:55Z | |
| dc.date.issued | 2021-03 | |
| dc.date.submitted | 2019-11 | |
| dc.identifier.issn | 1550-4131 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/135273.2 | |
| dc.description.abstract | Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture. | en_US |
| dc.language.iso | en | |
| dc.publisher | Elsevier BV | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.cmet.2021.01.001 | en_US |
| dc.rights | Creative Commons Attribution 4.0 International license | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.source | Elsevier | en_US |
| dc.title | A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density | en_US |
| dc.type | Article | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | |
| dc.relation.journal | Cell Metabolism | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2021-07-20T18:04:37Z | |
| dspace.orderedauthors | Sinnott-Armstrong, N; Sousa, IS; Laber, S; Rendina-Ruedy, E; Nitter Dankel, SE; Ferreira, T; Mellgren, G; Karasik, D; Rivas, M; Pritchard, J; Guntur, AR; Cox, RD; Lindgren, CM; Hauner, H; Sallari, R; Rosen, CJ; Hsu, YH; Lander, ES; Kiel, DP; Claussnitzer, M | en_US |
| dspace.date.submission | 2021-07-20T18:04:39Z | |
| mit.journal.volume | 33 | en_US |
| mit.journal.issue | 3 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work Needed | en_US |
