The metabolic landscape of RAS-driven cancers from biology to therapy
Author(s)
Mukhopadhyay, Suman; Vander Heiden, Matthew G; McCormick, Frank
DownloadAccepted version (1.946Mb)
Open Access Policy
Open Access Policy
Creative Commons Attribution-Noncommercial-Share Alike
Terms of use
Metadata
Show full item recordAbstract
Our understanding of how the RAS protein family, and in particular mutant KRAS promote metabolic dysregulation in cancer cells has advanced significantly over the last decade. In this Review, we discuss the metabolic reprogramming mediated by oncogenic RAS in cancer, and elucidating the underlying mechanisms could translate to novel therapeutic opportunities to target metabolic vulnerabilities in RAS-driven cancers.
Date issued
2021-03Department
Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of BiologyJournal
Nature Cancer
Publisher
Springer Science and Business Media LLC
ISSN
2662-1347