| dc.contributor.author | Antonucci, Jenna M | |
| dc.contributor.author | Gehrke, Lee | |
| dc.date.accessioned | 2021-12-13T15:30:32Z | |
| dc.date.available | 2021-12-08T19:19:57Z | |
| dc.date.available | 2021-12-13T15:30:32Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/138396.2 | |
| dc.description.abstract | Copyright © 2019 American Chemical Society. Across zoonotic pathogens, RNA viruses are responsible for disproportionate levels of human disease, suffering, and death. Neurotropic RNA viruses (e.g., rabies, Japanese and Eastern Equine Encephalitis, Ebola, West Nile, Powassan) infect the brain and spinal cord, causing meningitis, encephalitis, microcephaly, and Guillain-Barré syndrome. Mechanistic data explaining the molecular mechanisms of these diseases are lacking, and the enclosure of the central nervous system and the associated meninges in bone complicates access for diagnosis, clinical treatment, and research. Here, we discuss new tissue models, imaging methods, and molecular techniques that are changing research aimed at understanding the pathogenesis of neurotropic RNA viruses. | en_US |
| dc.description.sponsorship | U.S. Public Health Service (Award U19AI131135) | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | 10.1021/ACSINFECDIS.9B00339 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Cerebral Organoid Models for Neurotropic Viruses | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Antonucci, Jenna and Gehrke, Lee. 2019. "Cerebral Organoid Models for Neurotropic Viruses." ACS Infectious Diseases, 5 (12). | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
| dc.relation.journal | ACS Infectious Diseases | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2021-12-08T19:16:43Z | |
| dspace.orderedauthors | Antonucci, J; Gehrke, L | en_US |
| dspace.date.submission | 2021-12-08T19:16:44Z | |
| mit.journal.volume | 5 | en_US |
| mit.journal.issue | 12 | en_US |
| mit.license | PUBLISHER_POLICY | |
| mit.metadata.status | Publication Information Needed | en_US |
