| dc.contributor.author | Vasudevan, N. | |
| dc.contributor.author | Ahlqvist, Grace P. | |
| dc.contributor.author | McGeough, Catherine P. | |
| dc.contributor.author | Paymode, Dinesh J. | |
| dc.contributor.author | Cardoso, Flavio S. P. | |
| dc.contributor.author | Lucas, Tobias | |
| dc.contributor.author | Dietz, Jule-Phillip | |
| dc.contributor.author | Opatz, Till | |
| dc.contributor.author | Jamison, Timothy F. | |
| dc.contributor.author | Gupton, Frank B. | |
| dc.contributor.author | Snead, David R. | |
| dc.date.accessioned | 2022-05-09T20:29:09Z | |
| dc.date.available | 2022-03-09T15:25:53Z | |
| dc.date.available | 2022-05-09T20:29:09Z | |
| dc.date.issued | 2020-10 | |
| dc.date.submitted | 2020-09 | |
| dc.identifier.issn | 1359-7345 | |
| dc.identifier.issn | 1364-548X | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/141082.2 | |
| dc.description.abstract | © The Royal Society of Chemistry. A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of 75%, a significant advancement over the reported yield of 17%. The step count is reduced from five transformations to two, and expensive uridine is replaced with the more available cytidine. This journal is | en_US |
| dc.language.iso | en | |
| dc.publisher | Royal Society of Chemistry (RSC) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1039/d0cc05944g | en_US |
| dc.rights | Creative Commons Attribution NonCommercial License 3.0 | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ | en_US |
| dc.source | Royal Society of Chemistry (RSC) | en_US |
| dc.title | A concise route to MK-4482 (EIDD-2801) from cytidine | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Vasudevan, N, Ahlqvist, Grace P, McGeough, Catherine P, Paymode, Dinesh J, Cardoso, Flavio SP et al. 2020. "A concise route to MK-4482 (EIDD-2801) from cytidine." Chemical Communications, 56 (87). | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | |
| dc.relation.journal | Chemical Communications | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2022-03-09T15:24:03Z | |
| dspace.orderedauthors | Vasudevan, N; Ahlqvist, GP; McGeough, CP; Paymode, DJ; Cardoso, FSP; Lucas, T; Dietz, J-P; Opatz, T; Jamison, TF; Gupton, FB; Snead, DR | en_US |
| dspace.date.submission | 2022-03-09T15:24:05Z | |
| mit.journal.volume | 56 | en_US |
| mit.journal.issue | 87 | en_US |
| mit.license | PUBLISHER_CC | |
| mit.metadata.status | Authority Work Needed | en_US |
