A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2
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A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.
Date issued
2020-09Department
Massachusetts Institute of Technology. Department of ChemistryJournal
Synlett
Publisher
Georg Thieme Verlag KG
Citation
Gopalsamuthiram, Vijayagopal, Williams, Corshai, Noble, Jeffrey, Jamison, Tim, Gupton, B Frank et al. 2021. "A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2." Synlett, 32 (03). © 2021 Georg Thieme Verlag. All rights reserved.
Version: Original manuscript
ISSN
0936-5214
1437-2096