| dc.contributor.author | D’Angelo, Kyan A | |
| dc.contributor.author | Schissel, Carly K | |
| dc.contributor.author | Pentelute, Bradley L | |
| dc.contributor.author | Movassaghi, Mohammad | |
| dc.date.accessioned | 2022-03-10T20:27:04Z | |
| dc.date.available | 2022-03-10T20:27:04Z | |
| dc.date.issued | 2022-02-25 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/141147 | |
| dc.description.abstract | <jats:p>The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.</jats:p> | en_US |
| dc.language.iso | en | |
| dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
| dc.relation.isversionof | 10.1126/science.abm6509 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | chemRxiv | en_US |
| dc.title | Total synthesis of himastatin | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | D’Angelo, Kyan A, Schissel, Carly K, Pentelute, Bradley L and Movassaghi, Mohammad. 2022. "Total synthesis of himastatin." Science, 375 (6583). | |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | |
| dc.relation.journal | Science | en_US |
| dc.eprint.version | Original manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/NonPeerReviewed | en_US |
| dc.date.updated | 2022-03-10T20:22:32Z | |
| dspace.orderedauthors | D’Angelo, KA; Schissel, CK; Pentelute, BL; Movassaghi, M | en_US |
| dspace.date.submission | 2022-03-10T20:22:35Z | |
| mit.journal.volume | 375 | en_US |
| mit.journal.issue | 6583 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Authority Work and Publication Information Needed | en_US |
