| dc.contributor.author | Jun, Joomyung V. | |
| dc.contributor.author | Raines, Ronald T. | |
| dc.date.accessioned | 2022-03-17T14:22:13Z | |
| dc.date.available | 2022-03-16T18:06:45Z | |
| dc.date.available | 2022-03-17T14:22:13Z | |
| dc.date.issued | 2021-04 | |
| dc.date.submitted | 2021-03 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | https://hdl.handle.net/1721.1/141239.2 | |
| dc.description.abstract | α-Aryl-α-diazoamides were synthesized in two steps under mild conditions. This expeditious route employs Pd-catalyzed C-H arylation of N-succinimidyl 2-diazoacetate to obtain N-succinimidyl 2-aryl-2-diazoacetates, followed by aminolysis. The ensuing diazo compounds can esterify carboxyl groups in aqueous solution, and the ester products are substrates for an esterase. The broad scope of the synthetic route enables the continued development of diazo compounds in chemical biology. | en_US |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/acs.orglett.1c00793 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Two-Step Synthesis of α-Aryl-α-diazoamides as Modular Bioreversible Labels | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Jun, Joomyung V and Raines, Ronald T. 2021. "Two-Step Synthesis of α-Aryl-α-diazoamides as Modular Bioreversible Labels." Organic Letters, 23 (8). | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2022-03-16T18:02:58Z | |
| dspace.orderedauthors | Jun, JV; Raines, RT | en_US |
| dspace.date.submission | 2022-03-16T18:02:59Z | |
| mit.journal.volume | 23 | en_US |
| mit.journal.issue | 8 | en_US |
| mit.license | OPEN_ACCESS_POLICY | |
| mit.metadata.status | Authority Work Needed | en_US |
