Self-standing sub-cellular sized PhotoVoltaic devices for minimally-invasive and precise Neuronal Stimulation

Abstract

Neural stimulation is an important research tool for diagnosis, monitoring and therapeutics. It helps in deciphering neural connections and improving our understanding of how different parts of the brain works. In this thesis work, I will be discussing about designing for the first time sub-cellular sized Photovoltaic devices which can do spatio-temporally precise neuron stimulation. These devices are based on thin-film Organic Photovoltaic technology. The stimulating devices are roughly 250 nm in thickness and a few micrometers in size ( 5um in diameter). This thesis will provide for the first time a way of targeting individual neurons for stimulation without tissue displacement and help in developing novel technologies for therapeutics. Apart from brain stimulation, this technology can be used for targeting different cells like HEK, HELA, etc. which can get electrically stimulated.