E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6

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Hazan, Renin; Mori, Munemasa; Danielian, Paul S; Guen, Vincent J; Rubin, Seth M; ... Show more
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Abstract
<jats:p> Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplasmic role in multiciliogenesis. </jats:p>
Date issued
2021
URI
https://hdl.handle.net/1721.1/146881
Department
Massachusetts Institute of Technology. Department of Biology
Journal
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Citation
Hazan, Renin, Mori, Munemasa, Danielian, Paul S, Guen, Vincent J, Rubin, Seth M et al. 2021. "E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6." Molecular Biology of the Cell, 32 (20).
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