Biological and computational tools for systems biology : application to Fas signaling pathways in T cells
Author(s)Yokoo, Rayka, 1980-
Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Luk Van Parijs.
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With the development of new experimental technologies, biologists have begun to take a more global view into cell function, approaching its study in a more systematic manner than previously possible. This thesis develops three new tools to perform systems biology studies of cell death in T cells: A modeling program, JDesigner; high throughput T cell apoptosis assays; and an RNAi sequence prediction program. These tools are then applied to a biological and mathematical analysis of Fas signaling pathways in T cells.
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.Includes bibliographical references (leaves 43-44).
DepartmentMassachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.
Massachusetts Institute of Technology
Electrical Engineering and Computer Science.