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dc.contributor.advisorW. Eric L. Grimson.en_US
dc.contributor.authorGering, David T. (David Thomas), 1971-en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.en_US
dc.date.accessioned2005-09-26T19:30:25Z
dc.date.available2005-09-26T19:30:25Z
dc.date.copyright2003en_US
dc.date.issued2003en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/28275
dc.descriptionThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.en_US
dc.descriptionIncludes bibliographical references (p. 180-189).en_US
dc.description.abstractA framework is proposed for the segmentation of brain tumors from MRI. Instead of training on pathology, the proposed method trains exclusively on healthy tissue. The algorithm attempts to recognize deviations from normalcy in order to compute a fitness map over the image associated with the presence of pathology. The resulting fitness map may then be used by conventional image segmentation techniques for honing in on boundary delineation. Such an approach is applicable to structures that are too irregular, in both shape and texture, to permit construction of comprehensive training sets. We develop the method of diagonalized nearest neighbor pattern recognition, and we use it to demonstrate that recognizing deviations from normalcy requires a rich understanding of context. Therefore, we propose a framework for a Contextual Dependency Network (CDN) that incorporates context at multiple levels: voxel intensities, neighborhood coherence, intra-structure properties, inter-structure relationships, and user input. Information flows bi-directionally between the layers via multi-level Markov random fields or iterated Bayesian classification. A simple instantiation of the framework has been implemented to perform preliminary experiments on synthetic and MRI data.en_US
dc.description.statementofresponsibilityby David Thomas Gering.en_US
dc.format.extent189 p.en_US
dc.format.extent22398474 bytes
dc.format.extent22422856 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectElectrical Engineering and Computer Science.en_US
dc.titleRecognizing deviations from normalcy for brain tumor segmentationen_US
dc.typeThesisen_US
dc.description.degreePh.D.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
dc.identifier.oclc53276996en_US


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