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dc.contributor.advisorFrank B. Gertler.en_US
dc.contributor.authorMenzies, Annabelle Sheila, 1972-en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Biology.en_US
dc.date.accessioned2005-09-27T17:40:00Z
dc.date.available2005-09-27T17:40:00Z
dc.date.copyright2004en_US
dc.date.issued2004en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/28675
dc.descriptionThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2004.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.description.abstractNervous system development is a complex morphogenetic process. Cell migration, axon guidance and many other regulated cell shape changes build a functional nervous system. These processes depend upon regulation of the actin cytoskeleton. Ena/VASP proteins are able to remodel the actin cytoskeleton in response to extracellular signals and have been shown to regulate the motility and morphology of a variety of cells. I have investigated the in vivo requirement for the vertebrate family members, Mena and VASP in nervous system development. I show that Mena and VASP are required for viability and the formation of the neural tube, spinal nerves and several brain commissures. Furthermore, I have investigated Ena/VASP function in neuronal cell migration using an in vitro assay and demonstrate that Ena/VASP proteins regulate the migration of cerebellar granule cells.en_US
dc.description.statementofresponsibilityby Annabelle Sheila Menzies.en_US
dc.format.extent207 leavesen_US
dc.format.extent11545575 bytes
dc.format.extent11572292 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectBiology.en_US
dc.titleEna/VASP proteins regulate vertebrate nervous system development : a thesis presenteden_US
dc.typeThesisen_US
dc.description.degreePh.D.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Dept. of Biology.en_US
dc.identifier.oclc58995025en_US


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