| dc.contributor.advisor | Mary C. Boyce. | en_US |
| dc.contributor.author | Aronstam, Robert A. (Robert Andrew), 1979- | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Mechanical Engineering. | en_US |
| dc.date.accessioned | 2006-03-24T16:05:06Z | |
| dc.date.available | 2006-03-24T16:05:06Z | |
| dc.date.copyright | 2003 | en_US |
| dc.date.issued | 2002 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/29587 | |
| dc.description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, June 2002. | en_US |
| dc.description | Includes bibliographical references (leaves 32-33). | en_US |
| dc.description.abstract | An experimental study was performed to record and model the stress-strain behavior of a novel bioelastomer (PSG) during five one-week intervals of in vivo degradation. Also of interest were the changes in compressive Young's modulus of due to the degradation. Samples of PSG were implanted in Sprague-Dawley rats, extracted after each interval, and tested on a compression testing machine. The stress-strain behavior of the PSG was recorded and compared to two theoretical models: a Gaussian model and an 8-chain (non-Gaussian) model. The 8-chain model yielded the better predictions for the highly nonlinear PSG stress-strain behavior. The compressive Young's modulus for PSG decreased significantly after the first week of degradation, but remained relatively stable for the final four weeks. The proportional change in volume due to in vivo degradation of PSG was less than that of PLGA, a widely-used bioelastomer. Additionally, the PSG maintained its physical shape much better than PLGA. | en_US |
| dc.description.statementofresponsibility | by Robert A. Aronstam. | en_US |
| dc.format.extent | 33 leaves | en_US |
| dc.format.extent | 1381552 bytes | |
| dc.format.extent | 1381359 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | en_US |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | |
| dc.subject | Mechanical Engineering. | en_US |
| dc.title | Effects of in vivo degradation on mechanical behavior of a novel bioelastomer | en_US |
| dc.title.alternative | Effects of in vivo degradation on mechanical behavior of PSG | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | S.B. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | |
| dc.identifier.oclc | 52899235 | en_US |
