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dc.contributor.advisorVan J. Wedeen.en_US
dc.contributor.authorDou, Jiangang, 1972-en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Nuclear Engineering.en_US
dc.date.accessioned2006-03-24T18:11:20Z
dc.date.available2006-03-24T18:11:20Z
dc.date.copyright2002en_US
dc.date.issued2002en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/30008
dc.descriptionThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2002.en_US
dc.descriptionIncludes bibliographical references (leaves 107-115).en_US
dc.description.abstractThe myocardial structure-function relation is the key to understand the functional design of the ventricular myocardium. While the function of myocardial fibers has been extensively studied, the recently observed laminar organization (sheets) of myocardial fibers is not well understood. This thesis establishes noninvasive MRI methods, registered cardiac diffusion and strain MRI, to acquire information about myocardial sheet structure and myocardial strain under identical in vivo conditions, and thus defines the functional role of myocardial sheets. This methodology solves limitations of existing methods that require postmortem dissection, and can be applied to living humans at multiple time horizons in the cardiac cycle. To establish valid MRI methods to map myocardial structure, we present a new method for diffusion MRI in the beating heart that is insensitive to cardiac motion and strain. Using phantom and in vivo validations, we demonstrate that this method addresses the problem of motion sensitivity of diffusion MRI in the beating heart. We also map myocardial sheet and fiber structure during systole in normal humans and find evidence that sheet architecture undergoes remarkable changes during contraction. To establish valid MR methods to quantify myocardial strain, we present a new 3D phase contrast strain imaging using single-shot 3D EPI. Compared to previous phase contrast 3D strain methods, the new method realizes potential sensitivity of phase contrast EPI. It significantly improves image quality regarding noise and artifact, requires much shorter acquisition time, and can be quickly and automatically processed without operator supervision. Following validation using a strain phantom,en_US
dc.description.abstract(cont.) we demonstrate the validity of our 3D single-shot strain method in healthy in vivo human heart and brain. Using these methods, we acquire registered diffusion and strain MRI to provide quantitative maps of myocardial structure-function relations in living humans. From these quantitative maps, we are able to define for the first time accurate images of the functional role of myocardial sheets. We find that myocardial sheets contribute to ventricular thickening through all three cross-fiber strain components: sheet shear, sheet extension, and by previously undocumented sheet-normal thickening. Each of these mechanisms demonstrates remarkable spatial non-uniformity as well as inter-subject variability. In all cases, the contributions to thickening of fiber strains are small. Sheet function in normal humans is found to be heterogeneous and variable, contrasting with the previously demonstrated uniformity of fiber shortening. Future studies on myocardial structure-function relations must investigate the causes and extent of such heterogeneous properties of the myocardium. This thesis shows that MRI is a valid and effective tool for noninvasive study of myocardial mechanical function in humans.en_US
dc.description.statementofresponsibilityby Jiangang Dou.en_US
dc.format.extent115 leavesen_US
dc.format.extent6139026 bytes
dc.format.extent6138833 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectNuclear Engineering.en_US
dc.titleMapping myocardial structure-function relations with cardiac diffusion and strain MRIen_US
dc.typeThesisen_US
dc.description.degreePh.D.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Dept. of Nuclear Engineering.en_US
dc.identifier.oclc55012103en_US


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