| dc.contributor.advisor | Stephen L. Buchwald. | en_US |
| dc.contributor.author | Hirai, Satoko | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Chemistry. | en_US |
| dc.date.accessioned | 2006-03-29T18:49:22Z | |
| dc.date.available | 2006-03-29T18:49:22Z | |
| dc.date.copyright | 2005 | en_US |
| dc.date.issued | 2005 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/32490 | |
| dc.description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005. | en_US |
| dc.description | Includes bibliographical references. | en_US |
| dc.description.abstract | The asymmetric biaryl backbone of a dialkylbiphenyl phosphine ligand was developed, synthesized, and resolved. The application of the chiral phosphine ligand to the asymmetric Suzuki-Miyaura cross-coupling reaction was also investigated. This phosphine ligand has yielded promising results in the asymmetric Suzuki-coupling of hindered boronic acids with the electron-rich aryl bromide, 1-bromo-2- methoxynaphthalene, to synthesize biaryls in modest enantioselectivity. | en_US |
| dc.description.statementofresponsibility | by Satoko Hirai. | en_US |
| dc.format.extent | 64 p. | en_US |
| dc.format.extent | 2246142 bytes | |
| dc.format.extent | 2247943 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | en_US |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | |
| dc.subject | Chemistry. | en_US |
| dc.title | The synthesis and applications of a biaryl-based asymmetric phosphine ligand | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | S.M. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | |
| dc.identifier.oclc | 61858035 | en_US |
