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dc.contributor.advisorMartha Gray.en_US
dc.contributor.authorCotton, Dale M., 1982-en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Mechanical Engineering.en_US
dc.date.accessioned2006-05-15T20:33:31Z
dc.date.available2006-05-15T20:33:31Z
dc.date.copyright2005en_US
dc.date.issued2005en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/32835
dc.descriptionThesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.description.abstractThe primary goal of this work was to establish a model system wherein a controlled level of damage is induced to a sample of normal cartilage, such that damage and repair can be observed by the dGEMRIC method of MR imaging. Primarily this included the iterative design of a cartilage tissue holder and testing of its ability to approximate uniaxial diffusion, as well as observation of glycosaminoglycan degradation induced by ADAMTS using dGEMRIC and DMMB assays. The mean uniaxial degradation rate for 20nM ADAMTS was 0.17 mm/day ± 0.08 (1 [delta], n = 4). The shape of the diffusion front was mostly flat, with attributable factors such as vascular structures affecting the shape. These consistencies made ADAMTS an acceptable choice for a degradation agent in the model system. A final holder design was created that proved largely successful in limiting access of ADAMTS to a single surface, as demonstrated by the flat diffusion/degradation front. This led to a good approximation of uni-axial diffusion and fit well with simple mathematical models of diffusion and previously determined diffusivities of Gadolinium agents in cartilage. A model system using ADAMTS as a degradation agent and dGEMRIC methods of observation can now be implemented for exploration of cartilage's ability to repair itself.en_US
dc.description.statementofresponsibilityby Dale M. Cotton.en_US
dc.format.extent23 leavesen_US
dc.format.extent1705920 bytes
dc.format.extent1704004 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectMechanical Engineering.en_US
dc.titleExploring issues for a cartilage degradation modelen_US
dc.typeThesisen_US
dc.description.degreeS.B.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Dept. of Mechanical Engineering.en_US
dc.identifier.oclc60689177en_US


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