Evaluation of monolayer protected metal nanoparticle technology

Abstract

Self assembling nanostructured nanoparticles represent a new class of synthesized materials with unique functionality. Such monolayer protected metal nanoparticles are capable of resisting protein adsorption, and if utilized as a coating could have broad application in a wide range of industries from consumer products to maritime shipping to medical instruments. The formation of proteic films can adversely affect the performance of materials and is often a limiting factor in device effectiveness. In many instances such as sensors or medical implants, regular cleaning or disposal of the instrument is not a viable option, thus there exists a demand for additional means to prevent nonspecific protein adsorption. Existing protein resistant coating options are still not completely effective, and monolayer protected metal nanoparticle coatings could be a superior means by which to prevent protein adsorption onto material surfaces.

(cont.) This paper explores the commercialization potential of monolayer protected metal nanoparticle coatings for protein resistance; identifying application potential, evaluating potential markets, exploring intellectual property, analyzing the economics of monolayer protected metal nanoparticle synthesis, examining existing technologies, and assessing in depth the medical device industry and entry into the US cardiovascular device market.