| dc.contributor.advisor | Roger D. Kamm and Mohammad R. Kaazempur Mofrad. | en_US |
| dc.contributor.author | Zhu, Ting F. (Ting Fredrick) | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Mechanical Engineering. | en_US |
| dc.date.accessioned | 2006-08-25T18:55:43Z | |
| dc.date.available | 2006-08-25T18:55:43Z | |
| dc.date.copyright | 2005 | en_US |
| dc.date.issued | 2005 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/33907 | |
| dc.description | Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005. | en_US |
| dc.description | Includes bibliographical references (leaves 57-59). | en_US |
| dc.description.abstract | A numerical method has been developed to estimate the mechanical properties of atherosclerotic plaques by combining genetic algorithm with finite element methods. Plaque images derived from optical coherence tomography were employed to construct finite element models which were subsequently used in conjunction with a genetic algorithm to determine the parameters in a nonlinear constitutive model. A new multi-frame scheme is introduced to better perform the estimation on a nonlinear mechanical model and reduce the effects of noise. Results show while it is feasible to estimate the nonlinear mechanical properties of plaque, the accuracy can depend on various factors, especially the noise. KEY woRDS: FEM, atherosclerotic plaques, parameter estimation, Mooney-Rivlin model, optical coherence tomography, image noise. | en_US |
| dc.description.statementofresponsibility | by Ting F. Zhu. | en_US |
| dc.format.extent | 91 leaves | en_US |
| dc.format.extent | 3195834 bytes | |
| dc.format.extent | 3199589 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | en_US |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | |
| dc.subject | Mechanical Engineering. | en_US |
| dc.title | Estimation of nonlinear mechanical properties of atherosclerotic plaques | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | S.M. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | |
| dc.identifier.oclc | 66910312 | en_US |
