Lamination of a biodegradable polymeric microchip
Author(s)Kim, Jina, 1984-
Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.
Michael J. Cima.
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This work builds on the initial design of a polymer microchip for controlled-release drug delivery. Currently, the microchip employs a nonbiodegradable sealant layer, and the new design aims to fabricate it only of biodegradable parts. Experiments were conducted to evaluate two potential designs that are fabricated via lamination, and a final design was proposed based on the results. Design 1 sought to replace the sealant directly with a PLA backing layer, but the laminated backing layer was found to leak in 14C-dextran release experiments. Design 2 used a laminated film instead of the original injected membrane. The laminated film was optimized to a 200- [mu]m thick poly(D,L-lactic-co-glycolic acid) 2A membrane, and the film-laminated microchip was shown to release 14C-dextran within a 40-day period. The final proposed design was based on Design 2, which demonstrated more potential as a future means of drug delivery.
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.Includes bibliographical references (leaf 22).
DepartmentMassachusetts Institute of Technology. Dept. of Materials Science and Engineering.
Massachusetts Institute of Technology
Materials Science and Engineering.