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Understanding Oxidative Instability of Protein Pharmaceuticals
Mechanism of oxidation of methionine residues in protein pharmaceuticals by hydrogen peroxide was investigated via ab initio calculations. Specifically, two reactions, hydrogen transfer of hydrogen peroxide to form water ...
On the Oxidation of Methionine Residues during the Storage of Protein Pharmaceuticals in an Aqueous Formulation
This study addresses the fundamentals of an important degradation pathway of storing protein pharmaceuticals in an aqueous formulation, oxidation of methionine residues by peroxides. First, a mechanism by which methionine ...
Stabilization of Therapeutic Proteins
We present results of molecular simulations, quantum mechanical calculations, and experimental data aimed towards the rational design of solvent formulations. In particular, we have found that the rate limitation of oxidation ...