Browsing Molecular Engineering of Biological and Chemical Systems (MEBCS) by Title
Now showing items 42-61 of 106
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Machine Learning Approaches to Modeling the Physiochemical Properties of Small Peptides
(2006-01)Peptide and protein sequences are most commonly represented as a strings: a series of letters selected from the twenty character alphabet of abbreviations for the naturally occurring amino acids. Here, we experiment with ... -
Magnetophoresis of Nonmagnetic, Submicrometer Particles in Magnetic Fluids
(2004-01)We studied the migration of nonmagnetic, submicrometer polystyrene beads submerged in a magnetic fluid in the presence of nonuniform magnetic fields as a potential method for size-based separation of submicrometer, nonmagnetic ... -
MicroRNAs Modulate Hematopoietic Lineage Differentiation
(2005-01)MicroRNAs (miRNAs), an abundant class of ~22 nucleotide non-coding RNAs, are thought to play an important regulatory role in animal and plant development at the posttranscriptional level. Many miRNAs cloned from mouse bone ... -
Molecular computations for reactions and phase transitions: applications to protein stabilization, hydrates and catalysis
(2005-01)In this work we have made significant contributions in three different areas of interest: therapeutic protein stabilization, thermodynamics of natural gas clathrate-hydrates, and zeolite catalysis. In all three fields, ... -
Molecular Computations for the Stabilization of Therapeutic Proteins
(2004-01)Molecular computations based on quantum mechanics and statistical mechanics have been applied to the understanding and quantification of processes leading to the degradation of therapeutic proteins. In particular, we focus ... -
Molecular Engineering Approaches to Highly Structured Materials
(2004-01)Design and synthesis of novel supramolecular architectures is an interesting area of research in the last two decades. Intermolecular interactions assisted self-assembly of molecular and macromolecular building blocks play ... -
Molecular Engineering of Amphiphilic Pyridine Incorporated Conjugated Polymers for Metal Ion Sensors
(2004-01)Recent developments in the synthesis and structure-property investigation studies of conjugated polymers have led to the design of novel polymeric materials with tailored properties for advanced technological applications. ... -
Molecular Engineering of Conjugated Polymers for Sensor Applications
(2006-01)In recent years, the application of fluorescent conjugated polymers for sensing chemical and biological analytes has received much attention from many researchers. A promising development in this direction was the fabrication ... -
Molecular Study of Interactions between Hematopoietic Stem Cells and Stromal Cells
(2002-01)Multipotent hematopoietic stem cells (HSCs) are progenitors of all types of hematopoietic cells, and the efficient isolation and propagation of HSCs will significantly enhance our ability to manage many human disorders ... -
A Multi-scale Model for Copper Dishing in Chemical-Mechanical Polishing
(2005-01)The present success in the manufacture of multi-layer interconnects in ultra-large-scale integration is largely due to the acceptable planarization capabilities of the chemical-mechanical polishing (CMP) process. In the ... -
Nanoparticles for Targeted Drug Delivery
(2004-01)Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au<sub>2</sub>S nanoparticles. An anti-cancer drug (<i>cis-platin</i>) ... -
Near Infrared-Sensitive Nanoparticles for Targeted Drug Delivery
(2004-01)The invasive nature and undesirable side-effects related to conventional cancer therapy, such as surgery and chemotherapy, have led to the development of novel drug delivery systems (DDS). A minimally invasive DDS using ... -
A New Class of Nonionic Photosensitive Surfactants: Some Insights Concerning Conformations
(2005-01)We report on a new class of nonionic, photosensitive surfactants consisting of a polar di(ethylene oxide) head group attached to an alkyl spacer of between two and eight methylene groups, coupled through an ether linkage ... -
A New Class of Photoresponsive Surfactants
(2003-01)Recently, surface tension has been shown to be important in emerging high technologies, such as in pumping and control of flow in microfluidic devices, in microchemical analysis of complex fluids, and in rapid DNA screening, ... -
NIR-Sensitive Au-Au₂S Nanoparticles for Drug Delivery
(2003-01)Near IR (NIR) sensitive Au-Au₂S nanoparticles were prepared by mixing HAuCl₄ and Na₂S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au₂S nanoparticle surface via the 11-mercaptoundecanoic acid ... -
Novel pH Responsive Amphiphilic Diblock Copolymers with Reversible Micellization Properties
(2004-01)Di-block copolymer of poly[methacrylic acid-block-2-(diethylamino)ethyl methacrylate] [P(MAA-b-DEA)] with narrow molecular weight distribution was synthesized using the atom transfer radical polymerization (ATRP) technique. ... -
On the Electrostatics of Pneumatic Conveying of Granular Materials
(2004-01)In this work the electrostatics of the pneumatic conveying of granular materials in a non-conducting (PVC) vertical pipe is studied using Electrical Capacitance Tomography (ECT) system. The non-conducting wall in general ... -
On the Fabrication of Microparticles Using Electrohydrodynamic Atomization Method
(2005-01)A new approach for the control of the size of particles fabricated using the Electrohydrodynamic Atomization (EHDA) method is being developed. In short, the EHDA process produces solution droplets in a controlled manner, ... -
On the Oxidation of Methionine Residues during the Storage of Protein Pharmaceuticals in an Aqueous Formulation
(2004-01)This study addresses the fundamentals of an important degradation pathway of storing protein pharmaceuticals in an aqueous formulation, oxidation of methionine residues by peroxides. First, a mechanism by which methionine ... -
Over Expression of the CMP-sialic Acid Transporter in Chinese Hamster Ovary Cells Leads to Increased Sialylation
(2005-01)Most glyco-engineering approaches used to improve quality of recombinant glycoproteins involve the manipulation of glycosyltransferase and/or glycosidase expression. We investigated whether the over expression of nucleotide ...