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Stabilization of Therapeutic Proteins
(2003-01)
We present results of molecular simulations, quantum mechanical calculations, and experimental data aimed towards the rational design of solvent formulations. In particular, we have found that the rate limitation of oxidation ...
Stability of Granular Materials under Vertical Vibrations
(2003-01)
The influence of periodic vibrations on the granular flow of materials is of great interests to scientists and engineers due to both theoretical and practical reasons. In this paper, the stability of a vertically vibrated ...
Rheological and Thermodynamic Properties of PEO-PPE-PEO and PAA-g-PEO-PPO-PEO System
(2003-01)
Rheological and thermodynamic properties of Pluronic F127 copolymer and Pluronic-g-PAA have been studied as a function of temperature and concentration. A combination of rheometry and DSC was employed to examine the gelation ...
Computational Method for Drug Target Search and Application in Drug Discovery
(2003-01)
Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug. A protein structure database is searched to find proteins to which a drug can bind ...
Activation Ratios For Reconstruction Of Signal Transduction Networks
(2003-01)
We have developed a novel framework that can be applied for the analysis of signal transduction networks, both to facilitate reconstruction of the network structure and quantitatively characterize the interaction between ...
Computer-Aided Drug Target Search
(2003-01)
Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery. It can potentially help in several aspects including: (1) determination of unknown therapeutic ...
Glucose-Sensitive Nanoparticles for Controlled Insulin Delivery
(2003-01)
A novel reverse microemulsion (RM) mediated synthesis of glucose-responsive nanoparticles was developed for controlled insulin delivery. Nanoparticles were constructed using a model system comprised of dextran, poly(α-1,6 ...
Increasing The Odds Of Hit Iidentification By Screening Against Receptor Homologs
(2003-01)
Increasing the odds of hit identification in screening is of significance for drug discovery. The odds for finding a hit are closely related either to the diversity of libraries or to the availability of focused libraries. ...
Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces
(2003-01)
We have investigated a series of molecular and polymeric approaches for generating adherent thin films that impart anti-fouling characteristics to oxide surfaces. These films incorporate oligo- or poly(ethylene glycol) ...
NIR-Sensitive Au-Au₂S Nanoparticles for Drug Delivery
(2003-01)
Near IR (NIR) sensitive Au-Au₂S nanoparticles were prepared by mixing HAuCl₄ and Na₂S in aqueous solutions. An anti-tumor drug, cis-platin, was adsorbed onto Au-Au₂S nanoparticle surface via the 11-mercaptoundecanoic acid ...