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dc.contributor.advisorJames J. DiCarlo.en_US
dc.contributor.authorOreper, Daniel (Daniel G.)en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.en_US
dc.date.accessioned2007-04-03T17:09:42Z
dc.date.available2007-04-03T17:09:42Z
dc.date.copyright2006en_US
dc.date.issued2006en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/37082
dc.descriptionThesis (M. Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.en_US
dc.descriptionStatement of responsibility "by Daniel Oreper" taken from abstract, p. 1. Leaf 109 blank.en_US
dc.descriptionIncludes bibliographical references (leaf 108).en_US
dc.description.abstractNeuroscientists lack the ability to perform in-vivo electrode localization with high accuracy, especially in deep brain structures. The design, implementation and testing of a microfocal x-ray stereo system that offers an efficient, accurate, and relatively low-cost solution this localization problem is presented. The results indicate the ability to localize a targets to within -50 microns, in a brain-tissue-based frame. This accuracy is approximately twice as good as than the existing gold standard in electrophysiology (microlesions), and, unlike the microlesion method, the stereo microfocal x-ray method has important advantages. In particular, while only tens of neuronal recording sites can be reliably reconstructed with the microlesion method, microfocal x-ray method can be repeatedly performed to accurately estimate an essentially unlimited number of serial penetrations, and the localization results are available in nearly real time without animal sacrifice.en_US
dc.format.extent109 leavesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectElectrical Engineering and Computer Science.en_US
dc.titleHigh resolution in-vivo electrode localization using microfocal X-rays.en_US
dc.typeThesisen_US
dc.description.degreeM.Eng.and S.B.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.en_US
dc.identifier.oclc83299446en_US


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