Delivery of Etanidazole to Brain Tumor from PLGA Wafers
Name
MEBCS004.pdf
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12.04 KB
Format
Adobe PDF
Checksum (MD5)
3334744bdcf8004b30b7982bd47895c5
Author(s)
Tan, Wilson Hor Keong
Lee, Timothy
Wang, Chi-Hwa
Date Issued
January 2004
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
This paper presents the computer simulation results on the delivery of Etanidazole (radiosensitiser) to the brain tumor and examines several factors affecting the delivery. The simulation consists of a 3D model of tumor with poly (lactide-co-glycolide) (PLGA) wafers of 1% Etanidzole loading implanted in the resected cavity. A zero-order release device will produce a concentration profile in the tumor which increases with time until the drug in the carrier is depleted. This causes toxicity complications during the later stages of drug treatment. However, for wafers of similar loading, such release results in a higher drug penetration depth and therapeutic index as compared to the double drug burst profile. The numerical accuracy of the model was verified by the similar results obtained in the two-dimensional and three-dimensional models.
Subjects
drug delivery
computer simulations
3D computer models
brain tumor treatment
zero order release devices
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