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dc.contributor.advisorIan Hunter.en_US
dc.contributor.authorCunningham, Daniel (Daniel P.)en_US
dc.contributor.otherMassachusetts Institute of Technology. Dept. of Mechanical Engineering.en_US
dc.date.accessioned2008-02-27T22:22:25Z
dc.date.available2008-02-27T22:22:25Z
dc.date.copyright2007en_US
dc.date.issued2007en_US
dc.identifier.urihttp://hdl.handle.net/1721.1/40410
dc.descriptionThesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.en_US
dc.descriptionIncludes bibliographical references (leaf 15).en_US
dc.description.abstractDrug delivery through jet-injection opens the doors to very rapid drug dispersion by eliminating the need for needle sterilization. With this comes the need for a continuous flow of fluids from a large reservoir, currently not available to the single-piston drug delivery systems. A two-piston system in a jet injector enables the use of a cyclic motion of pistons to drive the injected fluids, as opposed to the one-piston design that requires resetting the mechanism. This provides a way to dispense high-volume doses of medication without reloading. In order to test the feasibility of using a two-piston arrangement in jet-injected drug delivery, we have constructed a bench-top version to attempt to achieve the velocities and flow rates needed for jet injection. Using water as the injected fluid, we have found that driving the two pistons with 1800 out-of-phase, 80% symmetric, saw-tooth waveforms and a frequency of 10 Hz is sufficient to inject 900 pIUs of water through the jet and maintain a pressure of more than 2 MPa.en_US
dc.description.statementofresponsibilityby Daniel Cunningham.en_US
dc.format.extent15 leavesen_US
dc.language.isoengen_US
dc.publisherMassachusetts Institute of Technologyen_US
dc.rightsM.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.en_US
dc.rights.urihttp://dspace.mit.edu/handle/1721.1/7582
dc.subjectMechanical Engineering.en_US
dc.titleThe dual-piston jet injector and the viability of drug deliveryen_US
dc.typeThesisen_US
dc.description.degreeS.B.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Dept. of Mechanical Engineering.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineering
dc.identifier.oclc191684457en_US


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