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Fabrication and function of microfluidic devices for monitoring of in-vitro fertilization processes

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dc.contributor.advisor Todd Thorsen. en_US
dc.contributor.author Xu, Jin (Jin C.) en_US
dc.contributor.other Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.date.accessioned 2008-03-27T18:24:36Z
dc.date.available 2008-03-27T18:24:36Z
dc.date.copyright 2007 en_US
dc.date.issued 2007 en_US
dc.identifier.uri http://hdl.handle.net/1721.1/40930
dc.description Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007. en_US
dc.description Includes bibliographical references (leaf 36). en_US
dc.description.abstract The process of assistive reproduction is often a headache and heartache for those who choose to go through it. The field currently relies heavily on morphological characteristics to determine embryo health and development success, a highly unreliable method. While they appear healthy at implantation, many embryos, in reality, have poor development potential and fail to survive within the womb. Therefore, to offset the high chances of miscarriage, multiple eggs are implanted in the uterus. This has occasionally lead to multi-fetal pregnancies, which have a higher maternal mortality risk, and, in general, is more physically demanding. This thesis researches a microfluidic device that aids in the crucial stages of in vitro- fertilization. The device allows for a fertilized egg to be cultured within, and provides the ability to carefully monitor its health through a series of metabolic assays, a better indication of embryo health. This microfluidic embryo health monitoring device is comprised of two layers of channel networks. It works through passing fluids along flow channels that are driven by control channels. The control layer, when pressurized with gas, operates as valves and peristaltic pumps along the flow layer to pump and transport fluids through the flow channels. As embryonic fluids are passed through the channels, the status of the fertilized egg can be monitored with metabolic assays taken of the embryo at various detection sites. en_US
dc.description.statementofresponsibility by Jin Xu. en_US
dc.format.extent 39 leaves en_US
dc.language.iso eng en_US
dc.publisher Massachusetts Institute of Technology en_US
dc.rights M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. en_US
dc.rights.uri http://dspace.mit.edu/handle/1721.1/7582 en_US
dc.subject Mechanical Engineering. en_US
dc.title Fabrication and function of microfluidic devices for monitoring of in-vitro fertilization processes en_US
dc.type Thesis en_US
dc.description.degree S.B. en_US
dc.contributor.department Massachusetts Institute of Technology. Dept. of Mechanical Engineering. en_US
dc.identifier.oclc 212409168 en_US


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