| dc.contributor.advisor | Timothy F. Jamison. | en_US |
| dc.contributor.author | Gehling, Victor S. (Victor Scott) | en_US |
| dc.contributor.other | Massachusetts Institute of Technology. Dept. of Chemistry. | en_US |
| dc.date.accessioned | 2008-12-11T18:23:59Z | |
| dc.date.available | 2008-12-11T18:23:59Z | |
| dc.date.copyright | 2008 | en_US |
| dc.date.issued | 2008 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1721.1/43766 | |
| dc.description | Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008. | en_US |
| dc.description | Vita. | en_US |
| dc.description | Includes bibliographical references. | en_US |
| dc.description.abstract | Progress towards the total synthesis of sieboldine A is described. This synthetic approach uses a nickel-catalyzed alkyne-ketone reductive cyclization to form the hydrindane core of the natural product in good yield and with excellent diastereoselectivity about the newly formed tertiary allylic alcohol ... The hydrindane product from this reductive cyclization can be transformed into the tetracyclic N,O-acetal which is two steps removed from the natural product 1. Efforts directed towards completion of the synthesis of 1 via a direct late-stage amine oxidation are presented ... | en_US |
| dc.description.statementofresponsibility | by Victor S. Gehling. | en_US |
| dc.format.extent | 166 p. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Massachusetts Institute of Technology | en_US |
| dc.rights | M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission. | en_US |
| dc.rights.uri | http://dspace.mit.edu/handle/1721.1/7582 | en_US |
| dc.subject | Chemistry. | en_US |
| dc.title | Studies directed towards the total synthesis of (+)-sieboldine A | en_US |
| dc.type | Thesis | en_US |
| dc.description.degree | Ph.D. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | |
| dc.identifier.oclc | 260326846 | en_US |
