Intramolecular [4 + 2] cycloadditions of conjugated enynes with highly strained cyclic alkenes
Massachusetts Institute of Technology. Dept. of Chemistry.
Rick L. Danheiser.
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Seven- and eight-membered carbocycles are key features in numerous naturally occurring organic substances, many of which are biologically important natural products. This thesis describes studies directed towards the development of a [4 + 3] annulation strategy for the synthesis of seven-membered carbocycles involving the intramolecular [4 + 2] cycloadditions of conjugated enynes with cyclopropenes. A new [4 + 4] annulation method has been developed for the synthesis of eight-membered carbocycles involving cycloadditions of cyclobutenones with conjugated enynes.
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.Vita.Includes bibliographical references.
DepartmentMassachusetts Institute of Technology. Dept. of Chemistry.
Massachusetts Institute of Technology