Silencing and recombination in yeast ribosomal DNA
Author(s)O'Kelly, Michael J. T
Massachusetts Institute of Technology. Dept. of Physics.
Alexander van Oudenaarden.
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A bioinformatic and laboratory investigation into S. cerevisiae's system for the maintenance and homogenization of rDNA. Eliminating mutations and heterogeneity in rDNA repeats is necessary evolutionarily, but harmful to individual organisms--and has been linked to aging-related pathology. We present a forensic investigation of this process using a new whole-genome shotgun dataset, and interpret the results in light of experimental results showing the dynamics of rDNA silencing and recombination in laboratory strains.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008.Includes bibliographical references (p. 129-132).
DepartmentMassachusetts Institute of Technology. Dept. of Physics.
Massachusetts Institute of Technology