Browsing MIT Open Access Articles by Author "O'Connell, Joyce"

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    • Synergistic interactions with PI3K inhibition that induce apoptosis 

      Zwang, Yaara; Chen, Casandra; Rinne, Mikael L; Doench, John G; Piccioni, Federica; e.a. (eLife Sciences Publications, Ltd, 2017-05)
      Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit ...