Now showing items 1-3 of 3

    • Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity 

      Sheppard, Hadley E; Dall’Agnese, Alessandra; Park, Woojun D; Shamim, M Hamza; Dubrulle, Julien; e.a. (Elsevier BV, 2021)
      © 2020 The Authors Sheppard et al. map the brachyury regulatory landscape in chordoma and explore its targeting using transcriptional CDK inhibition and targeted brachyury degradation. Brachyury is a highly selective ...
    • Transcription control by the ENL YEATS domain in acute leukaemia 

      Erb, Michael A.; Scott, Thomas G.; Li, Bin E.; Xie, Huafeng; Paulk, Joshiawa; e.a. (Nature Publishing Group, 2017-03)
      Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors ...
    • YY1 Is a Structural Regulator of Enhancer-Promoter Loops 

      Sigova, Alla A.; Hannett, Nancy M.; Day, Daniel S.; Abraham, Brian J.; Cohen, Malkiel A.; e.a. (Elsevier BV, 2017-12)
      There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and their ...