Browsing MIT Open Access Articles by Author "Naber, Stephen P."

Now showing items 1-3 of 3

The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis

Xu, Kun; Tian, Xuejun; Movassaghi, Mohammad; Kuperwasser, Charlotte; Oh, Sun Y.; e.a. (BioMed Central, 2016-01)

Background The tumor microenvironment has complex effects in cancer pathophysiology that are not fully understood. Most cancer therapies are directed against malignant cells specifically, leaving pro-malignant signals ...
Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells

Gupta, Piyush; Rudnick, Jenny A.; Arendt, Lisa M.; Klebba, Ina; Hinds, John W.; e.a. (Public Library of Science, 2011-09)

Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally ...
Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

Proia, Theresa A.; Keller, Patricia J.; Klebba, Ina; Jones, Ainsley D.; Sedic, Maja; e.a. (Elsevier, 2011-02)

Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast ...