Browsing MIT Open Access Articles by Title
Now showing items 21651-21670 of 37101
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N = 1 sigma models in AdS[subscript 4]
(Springer-Verlag, 2011-12)We study sigma models in AdS4 with global N = 1 supersymmetry and find that they differ significantly from their flat-space cousins — the target space is constrained to be a K¨ahler manifold with an exact K¨ahler form, ... -
N = 4 superconformal bootstrap of the K[subscript 3] CFT
(Springer Berlin Heidelberg, 2017-05)We study two-dimensional (4, 4) superconformal field theories of central charge c = 6, corresponding to nonlinear sigma models on K[subscript 3] surfaces, using the superconformal bootstrap. This is made possible through ... -
The N = 8 superconformal bootstrap in three dimensions
(Springer-Verlag, 2014-09)We analyze the constraints imposed by unitarity and crossing symmetry on the four-point function of the stress-tensor multiplet of N=8 superconformal field theories in three dimensions. We first derive the superconformal ... -
¹⁵N and ¹H Solid-State NMR Investigation of a Canonical Low-Barrier Hydrogen-Bond Compound: 1,8-Bis(dimethylamino)naphthalene
(American Chemical Society (ACS), 2017-06-29)Strong or low-barrier hydrogen bonds have often been proposed in proteins to explain enzyme catalysis and proton-transfer reactions. So far ¹H chemical shifts and scalar couplings have been used as the main NMR spectroscopic ... -
N Jettiness: An Inclusive Event Shape to Veto Jets
(American Physical Society, 2010-08)Jet vetoes are essential in many analyses at the LHC and Tevatron. Typical signals have a specific number of hard jets or leptons, while backgrounds have additional jets. Vetoing undesired jets efficiently discriminates ... -
An n →π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole
(American Chemical Society (ACS), 2019-02)Aspartic proteases regulate many biological processes and are prominent targets for therapeutic intervention. Structural studies have captured intermediates along the reaction pathway, including the Michaelis complex and ... -
n →π* Interactions Modulate the Properties of Cysteine Residues and Disulfide Bonds in Proteins
(American Chemical Society (ACS), 2018-12)Noncovalent interactions are ubiquitous in biology, taking on roles that include stabilizing the conformation of and assembling biomolecules, and providing an optimal environment for enzymatic catalysis. Here, we describe ... -
N-Face GaN/AlGaN HEMTs Fabricated Through Layer Transfer Technology
(Institute of Electrical and Electronics Engineers, 2009-01)We present a new method to fabricate N-face GaN/AlGaN high electron mobility transistors (HEMTs). These devices are extremely promising for ultrahigh frequency applications where low contact resistances and excellent carrier ... -
N-jettiness subtractions for gg → H at subleading power
(American Physical Society, 2018-01)N-jettiness subtractions provide a general approach for performing fully-differential next-to-next-to-leading order (NNLO) calculations. Since they are based on the physical resolution variable N-jettiness, T[subscript N], ... -
N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus
(Public Library of Science, 2015-06)In all three domains of life, N-glycosylation begins with the assembly of glycans on phosphorylated polyisoprenoid carriers. Like eukaryotes, archaea also utilize phosphorylated dolichol for this role, yet whereas the ... -
N-methyl d-Aspartate Channels Link Ammonia and Epithelial Cell Death Mechanisms in Helicobacter pylori Infection
(Elsevier BV, 2011-09)Background & Aims: Helicobacter pylori infection is a risk factor for gastric cancer. Ammonia/ammonium (A/A) is a cytotoxin generated by H pylori that kills gastric epithelial cells. We investigated whether A/A cytotoxicity ... -
N-polar AlN buffer growth by MOVPE for transistor applications
(Japan Society of Applied Physics, 2018)We present the electrical characterization of N-polar AlN layers grown by metal-organic vapor phase epitaxy and the demonstration of N-polar AlN-channel metal-semiconductor field-effect transistors (MESFETs). A high ... -
n-relative categories: a model for the homotopy theory of n-fold homotopy theories
(International Press of Boston, Inc., 2013-12)We introduce, for every integer n ≥ 1, the notion of an n-relative category and show that the category of the small n-relative categories is a model for the homotopy theory of n-fold homotopy theories, i.e., homotopy ... -
An N-stage cascade of phosphorylation cycles as an insulation device for synthetic biological circuits
(Institute of Electrical and Electronics Engineers (IEEE), 2016-07)Single phosphorylation cycles have been found to have insulation device abilities, that is, they attenuate the effect of retroactivity applied by downstream systems and hence facilitate modular design in synthetic biology. ... -
N-Substituted 2-Aminobiphenylpalladium Methanesulfonate Precatalysts and Their Use in C–C and C–N Cross-Couplings
(2014-04)A series of phosphine-ligated palladium precatalysts based on N-methyl- and N-phenyl-2-aminobiphenyl have been developed. Substitution at the nitrogen center prevents the presence of traces of aminobiphenyls that contain ... -
N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
(Springer Science and Business Media LLC, 2018-01)Internal N 6-methyladenosine (m6A) modification is widespread in messenger RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) and Mettl14. To understand the role of m6A in development, ... -
N[superscript 6]-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N[superscript 6]-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats
(American Chemical Society (ACS), 2017-07)Exposure to both endogenous and exogenous formaldehyde has been established to be carcinogenic, likely by virtue of forming nucleic acid and proteins adducts such as N[superscript 6]-formyllysine. To better assess N[superscript ... -
NAD + supplementation rejuvenates aged gut adult stem cells
(Wiley, 2019-03)The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, ... -
NAD+ and sirtuins in aging and disease
(Elsevier, 2014-08)Nicotinamide adenine dinucleotide (NAD[superscript +]) is a classical coenzyme mediating many redox reactions. NAD[superscript +] also plays an important role in the regulation of NAD[superscript +]-consuming enzymes, ... -
The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
(Elsevier, 2013-07)NAD[superscript +] is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD[superscript +] levels are reduced in aged mice and Caenorhabditis elegans ...
