Browsing MIT Open Access Articles by Title
Now showing items 27992-28011 of 49563
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Molecular Modeling and Mechanics of Acrylic Adhesives on a Graphene Substrate with Roughness
(Springer US, 2016-06)Understanding the mechanics of amorphous polymeric adhesives on a solid substrate at the fundamental scale level is critical for designing and optimizing the mechanics of composite materials. Using molecular dynamics ... -
Molecular movement in the Arabidopsis thaliana female gametophyte
(Springer Science and Business Media LLC, 2017-07)Cellular decisions can be influenced by information communicated from neighboring cells. Communication can occur via signaling or through the direct transfer of molecules. Movement of RNAs and proteins has frequently been ... -
Molecular MRI of collagen to diagnose and stage liver fibrosis
(Elsevier, 2013-11)Background & Aims: The gold standard in assessing liver fibrosis is biopsy despite limitations like invasiveness and sampling error and complications including morbidity and mortality. Therefore, there is a major unmet ... -
Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun-Regulated Macrophage Activation
(American Association for the Advancement of Science (AAAS), 2014-02)Clinical management of endometriosis is limited by the complex relationship between symptom severity, heterogeneous surgical presentation, and variability in clinical outcomes. As a complement to visual classification ... -
Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice
(Royal Society of Chemistry, 2013-05)Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b[superscript ... -
Molecular Niobium Precursors in Various Oxidation States: An XAS Case Study
(American Chemical Society (ACS), 2018-10)Although X-ray absorption spectroscopy (XAS) has become an indispensable tool in characterization of solid-state materials, it is less of a staple in molecular chemistry of niobium. Scattering X-ray techniques remain ... -
Molecular Orientation and Alignment by Intense Single-Cycle THz Pulses
(American Physical Society (APS), 2011-10)Intense single-cycle THz pulses resonantly interacting with molecular rotations are shown to induce field-free orientation and alignment under ambient conditions. We calculate and measure the degree of both orientation and ... -
The Molecular Origin and Consequences of Escape from miRNA Regulation by HLA-C Alleles
(Elsevier B.V., 2011-09)Differential expression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-148a, to the 3′ untranslated region of some, but not all, HLA-C alleles. The binding results in lower ... -
Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes
(American Association for the Advancement of Science, 2009-04)Activation of Ras proteins underlies functional decisions in diverse cell types. Two molecules, Ras-GRP and SOS (Ras–guanine nucleotide–releasing protein and Son of Sevenless, respectively), catalyze Ras activation in ... -
Molecular origin of strain softening in cross-linked F-actin networks
(American Physical Society, 2010-07)Two types of measurement are presented that relate molecular events to macroscopic behavior of F-actin networks. First, shear modulus is measured by oscillating an embedded microbead. Second, a microbead is translated at ... -
Molecular origin of viscoelasticity in mineralized collagen fibrils
(Royal Society of Chemistry (RSC), 2021)<p>Bone is mineralized tissue constituting the skeletal system, supporting and protecting the body's organs and tissues. We unveil the molecular origins of its viscoelasticity with a full atomistic model.</p> -
Molecular origin of viscoelasticity in mineralized collagen fibrils
(Royal Society of Chemistry (RSC), 2021-03)<p>Bone is mineralized tissue constituting the skeletal system, supporting and protecting the body's organs and tissues. We unveil the molecular origins of its viscoelasticity with a full atomistic model.</p> -
Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR- Pathway
(American Association for Cancer Research (AACR), 2016-10)Peroxisome proliferator-activated receptor delta (PPAR-8) is a nuclear receptor transcription factor that regulates gene expression during development and disease states, such as cancer. However, the precise role of PPAR-8 ... -
Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer
(American Association for Cancer Research (AACR), 2016-11)Proteases known as sheddases cleave the extracellular domains of their substrates from the cell surface. The A Disintegrin and Metalloproteinases ADAM10 and ADAM17 are among the most prominent sheddases, being widely ... -
Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
(Springer Science and Business Media LLC, 2020-10)Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We ... -
A Molecular Precursor to Phosphaethyne and Its Application in Synthesis of the Aromatic 1,2,3,4-Phosphatriazolate Anion
(American Chemical Society (ACS), 2016-05)Dibenzo-7-phosphanorbornadiene Ph[subscript 3]PC(H)PA (1, A = C[subscript 14]H[subscript 10], anthracene) is reported here as a molecular precursor to phosphaethyne (HC≡P), produced together with anthracene and triphenylphosphine. ... -
THE MOLECULAR PROPERTIES OF GALACTIC H II REGIONS
(IOP Publishing, 2009-03)We derive the molecular properties for a sample of 301 Galactic H II regions including 123 ultra compact (UC), 105 compact, and 73 diffuse nebulae. We analyze all sources within the BU-FCRAO Galactic Ring Survey (GRS) of ... -
Molecular Representation: Going Long on Fingerprints
(Elsevier BV, 2020-05)Machine learning for chemistry requires a strategy for representing (featurizing) molecules. In this issue of Chem, Sandfort et al. describe an approach that concatenates 24 fingerprint representations into 71,375-dimensional ... -
Molecular sampling of prostate cancer: a dilemma for predicting disease progression
(BioMed Central Ltd., 2010-03)Background: Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict disease ... -
Molecular Signatures of Human Induced Pluripotent Stem Cells Highlight Sex Differences and Cancer Genes
(Elsevier B.V., 2012-07)Although human induced pluripotent stem cells (hiPSCs) have enormous potential in regenerative medicine, their epigenetic variability suggests that some lines may not be suitable for human therapy. There are currently few ...
