Browsing MIT Open Access Articles by Title
Now showing items 28032-28051 of 49488
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Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells
(Wiley Blackwell, 2014-11)Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high-affinity synthetic pThr-containing ... -
Mono-Model Parameter Joint Inversion by Gramian Constraints: EM Methods Examples
(American Geophysical Union (AGU), 2019-05-01)©2019. The Authors. Joint inversions of coincident geophysical data are usually constrained to produce more reliable subsurface models. Structural, petrophysical, model parameter correlation, empirical, and transforms are ... -
Monoacylglycerol lipase contributes to pathogenesis of Alzheimer's disease
(Elsevier, 2012-07)Alzheimer’s disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression. Monoacylglycerol lipase (MAGL) ... -
Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
(Elsevier B.V., 2012-11)Alzheimer's disease (AD) is the most common cause of dementia among older people. There are no effective medications currently available to prevent and treat AD and halt disease progression. Monoacylglycerol lipase (MAGL) ... -
Monoamine Biosynthesis via a Noncanonical Calcium-Activatable Aromatic Amino Acid Decarboxylase in Psilocybin Mushroom
(American Chemical Society (ACS), 2018-11-28)Aromatic l-amino acid decarboxylases (AAADs) are a phylogenetically diverse group of enzymes responsible for the decarboxylation of aromatic amino acid substrates into their corresponding aromatic arylalkylamines. AAADs ... -
Monoaryloxide Pyrrolide (MAP) Imido Alkylidene Complexes of Molybdenum and Tungsten That Contain 2,6-Bis(2,5-R[subscript 2]-pyrrolyl)phenoxide (R = i-Pr, Ph) Ligands and an Unsubstituted Metallacyclobutane on Its Way to Losing Ethylene
(American Chemical Society (ACS), 2013-05)We report the synthesis of Mo and W MAP complexes that contain O-2,6-(2,5-R[subscript 2]-pyrrolyl)[subscript 2]C[subscript 6]H[subscript 3] (2,6-dipyrrolylphenoxide or ODPP[superscript R]) ligands in which R = i-Pr, Ph. ... -
Monochromatic triangles, intermediate matrix products, and convolutions
(2020)© Andrea Lincoln, Adam Polak, and Virginia Vassilevska Williams. The most studied linear algebraic operation, matrix multiplication, has surprisingly fast O(nω) time algorithms for ω < 2.373. On the other hand, the (min, ... -
Monochromatic X-ray Source Based on Scattering from a Magnetic Nanoundulator
(American Chemical Society (ACS), 2020-04)We present a novel design for an ultracompact, passive light source capable of generating ultraviolet and X-ray radiation, based on the interaction of free electrons with the magnetic near-field of a ferromagnet. Our design ... -
Monochromatic X-ray Source Based on Scattering from a Magnetic Nanoundulator
(American Chemical Society (ACS), 2020-04)Copyright © 2020 American Chemical Society. We present a novel design for an ultracompact, passive light source capable of generating ultraviolet and X-ray radiation, based on the interaction of free electrons with the ... -
Monochromatic X-ray Source Based on Scattering from a Magnetic Nanoundulator
Copyright © 2020 American Chemical Society. We present a novel design for an ultracompact, passive light source capable of generating ultraviolet and X-ray radiation, based on the interaction of free electrons with the ... -
Monocular image space tracking on a computationally limited MAV
(Institute of Electrical and Electronics Engineers (IEEE), 2015-05)We propose a method of monocular camera-inertial based navigation for computationally limited micro air vehicles (MAVs). Our approach is derived from the recent development of parallel tracking and mapping algorithms, but ... -
Monocular SLAM Supported Object Recognition
(2015-07)In this work, we develop a monocular SLAM-aware object recognition system that is able to achieve considerably stronger recognition performance, as compared to classical object recognition systems that function on a ... -
Monocyclic aromatic amines as potential human carcinogens: old is new again
(Oxford University Press, 2009-12)Alkylanilines are a group of chemicals whose ubiquitous presence in the environment is a result of the multitude of sources from which they originate. Exposure assessments indicate that most individuals experience lifelong ... -
Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice
(American Heart Association, 2013-04)Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, ... -
Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse
(Elsevier, 2015-05)Background & Aims Regeneration of the hepatic mass is crucial to liver repair. Proliferation of hepatic parenchyma is intimately dependent on angiogenesis and resident macrophage-derived cytokines. However the role of ... -
Monofunctional and Higher-Valent Platinum Anticancer Agents
(American Chemical Society (ACS), 2013-06)Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have ... -
Monofunctional Platinum-DNA Adducts Are Strong Inhibitors of Transcription and Substrates for Nucleotide Excision Repair in Live Mammalian Cells
(American Association for Cancer Research, 2011-12)To overcome drug resistance and reduce the side effects of cisplatin, a widely used antineoplastic agent, major efforts have been made to develop next generation platinum-based anticancer drugs. Because cisplatin–DNA adducts ... -
Monolayer graphene membranes for molecular separation in high-temperature harsh organic solvents
(Proceedings of the National Academy of Sciences, 2021-09-14)The excellent thermal and chemical stability of monolayer graphene makes it an ideal material for separations at high temperatures and in harsh organic solvents. Here, based on understanding of solvent permeation through ... -
Monolayer graphene membranes for molecular separation in high-temperature harsh organic solvents
(National Academy of Sciences, 2021-09)The excellent thermal and chemical stability of monolayer graphene makes it an ideal material for separations at high temperatures and in harsh organic solvents. Here, based on understanding of solvent permeation through ... -
Monolayer Hexagonal Boron Nitride: An Efficient Electron Blocking Layer in Organic Photovoltaics
(Wiley, 2021-04-22)In this study, monolayer hexagonal boron nitride (h-BN) grown via chemical vapor deposition (CVD) as an effective electron blocking layer (EBL) for the organic photovoltaics (OPVs) is proposed. Unexpectedly, it is found ...
