Now showing items 1-2 of 2

    • Impact of oncogenic pathways on evasion of antitumour immune responses 

      Spranger, Stefani (Springer Science and Business Media LLC, 2018-01-12)
      Immunotherapeutic interventions are showing effectiveness across a wide range of cancer types, but only a subset of patients shows clinical response to therapy. Responsiveness to checkpoint blockade immunotherapy is favoured ...
    • Increased PHGDH expression promotes aberrant melanin accumulation 

      Mattaini, Katherine R.; Sullivan, Mark R.; Lau, Allison N.; Fiske, Brian P.; Vander Heiden, Matthew G. (Springer Science and Business Media LLC, 2019-07-22)
      Background: Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods: In order ...