Now showing items 1-2 of 2

    • CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling 

      Chen, Sidi; Zhou, Yang; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; e.a. (Elsevier, 2014-09)
      CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in ...
    • Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses 

      Avraham, Roi; Brown, Douglas; Penaranda, Cristina; Jijon, Humberto B.; Trombetta, John J.; e.a. (Elsevier, 2015-09)
      Encounters between immune cells and invading bacteria ultimately determine the course of infection. These interactions are usually measured in populations of cells, masking cell-to-cell variation that may be important for ...